Mitochondrial dysfunction in heart failure

Mitochondrial dysfunction in heart failure.

angina was reached. Angina, unfortunately, is a subjective measure. Irrespective of how “objective” the investigators were in determining the success or failure of antianginal therapy, the use of a subjective end point may have inadvertently introduced bias into the trial. It is difficult to draw proper conclusions from such a trial when large crossover rates are allowed. With respect to the Eu...

Mitochondrial dysfunction in heart failure: potential for therapeutic interventions?

a , b,c * William C. Stanley , Charles L. Hoppel Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4970, USA Departments of Pharmacology and Medicine, Case Western Reserve University, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-4970, USA Veterans Affairs Medical...

Sarcomeric dysfunction in heart failure.

Sarcomeric dysfunction plays a central role in reduced cardiac pump function in heart failure. This review focuses on the alterations in sarcomeric proteins in diseased myocardium that range from altered isoform expression to post-translational protein changes such as proteolysis and phosphorylation. Recent studies in animal models of heart failure and human failing myocardium converge and indi...

Endothelial dysfunction in heart failure.

Endothelial dysfunction crucially contributes to the development of impaired coronary and systemic perfusion as well as reduced exercise capacity in patients with congestive heart failure, with fundamental impact on morbidity and mortality. Reduced bioavailability of nitric oxide (NO) and abundant formation of reactive oxygen species (ROS) within the vascular wall are the key determinants in en...

Oxidative Posttranslational Modifications Develop LONP1 Dysfunction in Pressure Overload Heart Failure Hoshino et al: Mitochondrial Protease Compromise in Heart Failure